Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors

Resistance to antivirals is a complex and dynamic phenomenon that involves more mutations than are currently known. Here, we characterize 10 additional mutations (L74V, K101Q, I135M/T, V179I, H221Y, K223E/Q, and L228H/R) in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase which are...

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Detalhes bibliográficos
Main Authors: Ceccherini-Silberstein, Francesca, Svicher, Valentina, Sing, Tobias, Artese, Anna, Santoro, Maria Mercedes, Forbici, Federica, Bertoli, Ada, Alcaro, Stefano, Palamara, Guido, d'Arminio Monforte , Antonella, Balzarini, Jan, Antinori , Andrea, Lengauer, Thomas, Perno, Carlo Federico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045529/
https://ncbi.nlm.nih.gov/pubmed/17686836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00303-07
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