High throughput screening assay to identify small molecule inhibitors of Marburg virus VP40 protein

Marburg virus (MARV) causes sporadic outbreaks of severe disease with high case fatality rates in humans. To date, neither therapeutics nor prophylactic approaches have been approved for MARV disease. The MARV matrix protein VP40 (mVP40) plays central roles in virus assembly and budding. mVP40 also...

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發表在:ACS Infect Dis
Main Authors: Luthra, Priya, Anantpadma, Manu, De, Sampriti, Sourimant, Julien, Davey, Robert A., Plemper, Richard K., Basler, Christopher F.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793242/
https://ncbi.nlm.nih.gov/pubmed/32870648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00512
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