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High throughput screening assay to identify small molecule inhibitors of Marburg virus VP40 protein

Marburg virus (MARV) causes sporadic outbreaks of severe disease with high case fatality rates in humans. To date, neither therapeutics nor prophylactic approaches have been approved for MARV disease. The MARV matrix protein VP40 (mVP40) plays central roles in virus assembly and budding. mVP40 also...

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Publicado en:ACS Infect Dis
Main Authors: Luthra, Priya, Anantpadma, Manu, De, Sampriti, Sourimant, Julien, Davey, Robert A., Plemper, Richard K., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793242/
https://ncbi.nlm.nih.gov/pubmed/32870648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00512
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