Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visuali...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Loughran, H. Marie, Han, Ziying, Wrobel, Jay E., Decker, Sarah E., Ruthel, Gordon, Freedman, Bruce D., Harty, Ronald N., Reitz, Allen B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955528/
https://ncbi.nlm.nih.gov/pubmed/27377328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.06.053
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