Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visuali...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Loughran, H. Marie, Han, Ziying, Wrobel, Jay E., Decker, Sarah E., Ruthel, Gordon, Freedman, Bruce D., Harty, Ronald N., Reitz, Allen B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955528/
https://ncbi.nlm.nih.gov/pubmed/27377328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.06.053
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