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Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visuali...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Loughran, H. Marie, Han, Ziying, Wrobel, Jay E., Decker, Sarah E., Ruthel, Gordon, Freedman, Bruce D., Harty, Ronald N., Reitz, Allen B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955528/
https://ncbi.nlm.nih.gov/pubmed/27377328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.06.053
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