Ebola virus VP24 targets a unique NLS-binding site on karyopherin5 to selectively compete with nuclear import of phosphorylated STAT1

During anti-viral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) nuclear transporters. Many viruses, including Ebola virus, actively antagonize STAT1 signaling to counteract the antivir...

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Autori principali: Xu, Wei, Edwards, Megan R., Borek, Dominika M., Feagins, Alicia R., Mittal, Anuradha, Alinger, Joshua B., Berry, Kayla N., Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J., Pappu, Rohit V., Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188415/
https://ncbi.nlm.nih.gov/pubmed/25121748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.07.008
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