VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability

Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties. VP24 protein, a structural protein present in all family members, blocks interferon (IFN) signaling and likely contributes to virulence. Inhibitio...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Schwarz, Toni M., Edwards, Megan R., Diederichs, Audrey, Alinger, Joshua B., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286879/
https://ncbi.nlm.nih.gov/pubmed/27974555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01715-16
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