Use of medical care biases associations between Parkinson disease and other medical conditions

Por Gross, Anat, Racette, Brad A., Camacho-Soto, Alejandra, Dube, Umber, Searles Nielsen, Susan
Publicado no Neurology (2018)

Well Water and Parkinson Disease in Medicare Beneficiaries: A Nationwide Case-Control Study

Por Silver, Maya R., Racette, Brad A., Dube, Umber, Faust, Irene M., Nielsen, Susan Searles
Publicado no J Parkinsons Dis (2020)

TMEM230 IN PARKINSON’S DISEASE

Por Ibanez, Laura, Dube, Umber, Budde, John, Black, Kathleen, Medvedeva, Alexandra, Davis, Albert A., Perlmutter, Joel S., Benitez, Bruno A., Cruchaga, Carlos
Publicado no Neurobiol Aging (2017)

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

Por Dube, Umber, Ibanez, Laura, Budde, John P, Benitez, Bruno A, Davis, Albert A, Harari, Oscar, Iles, Mark M, Law, Matthew H, Brown, Kevin M, Cruchaga, Carlos
Publicado no Acta Neuropathol (2019)

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Por Ibanez, Laura, Dube, Umber, Saef, Benjamin, Budde, John, Black, Kathleen, Medvedeva, Alexandra, Del-Aguila, Jorge L., Davis, Albert A., Perlmutter, Joel S., Harari, Oscar, Benitez, Bruno A., Cruchaga, Carlos
Publicado no BMC Neurol (2017)

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease

Por Ibanez, Laura, Dube, Umber, Davis, Albert A., Fernandez, Maria V., Budde, John, Cooper, Breanna, Diez-Fairen, Monica, Ortega-Cubero, Sara, Pastor, Pau, Perlmutter, Joel S., Cruchaga, Carlos, Benitez, Bruno A.
Publicado no Front Neurosci (2018)

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Por Jiang, Shan, Wen, Natalie, Li, Zeran, Dube, Umber, Del Aguila, Jorge, Budde, John, Martinez, Rita, Hsu, Simon, Fernandez, Maria V., Cairns, Nigel J., Harari, Oscar, Cruchaga, Carlos, Karch, Celeste M.
Publicado no Transl Psychiatry (2018)

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

Por Fernández, Maria Victoria, Kim, Jong Hun, Budde, John P., Black, Kathleen, Medvedeva, Alexandra, Saef, Ben, Deming, Yuetiva, Del-Aguila, Jorge, Ibañez, Laura, Dube, Umber, Harari, Oscar, Norton, Joanne, Chasse, Rachel, Morris, John C., Goate, Alison, Cruchaga, Carlos
Publicado no PLoS Genet (2017)

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Por Li, Zeran, Del-Aguila, Jorge L., Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J., Dougherty, Joseph D., Lee, Jin-Moo, Morris, John C., Bateman, Randall J., Karch, Celeste M., Cruchaga, Carlos, Harari, Oscar
Publicado no Genome Med (2018)

OVERLAP IN THE GENETIC ARCHITECTURE OF STROKE RISK, EARLY NEUROLOGICAL CHANGES AND CARDIOVASCULAR RISK FACTORS

Por Ibanez, Laura, Heitsch, Laura, Dube, Umber, Farias, Fabiana H. G., Budde, John, Bergmann, Kristy, Davenport, Rich, Bradley, Joseph, Carrera, Caty, Kinnunen, Janne, Sallinen, Hanne, Strbian, Daniel, Slowik, Agnieszka, Fernandez-Cadenas, Israel, Montaner, Joan, Lee, Jin-Moo, Cruchaga, Carlos
Publicado no Stroke (2019)

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Por Del-Aguila, Jorge L., Benitez, Bruno A., Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A., Budde, John P., Farias, Fabiana H. G., Fernández, Maria Victoria, Ibanez, Laura, Jiang, Shan, Perrin, Richard J., Cairns, Nigel J., Morris, John C., Harari, Oscar, Cruchaga, Carlos
Publicado no Mol Neurodegener (2019)

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Por Del-Aguila, Jorge L., Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A., Budde, John P., Fernandez, Maria Victoria, Ibanez, Laura, Bradley, Joseph, Wang, Fengxian, Bergmann, Kristy, Davenport, Richard, Morris, John C., Holtzman, David M., Perrin, Richard J., Benitez, Bruno A., Dougherty, Joseph, Cruchaga, Carlos, Harari, Oscar
Publicado no Alzheimers Res Ther (2019)

APOE Genotype Regulates Pathology and Disease Progression in Synucleinopathy

Por Davis, Albert A., Inman, Casey E., Wargel, Zachary M., Dube, Umber, Freeberg, Brittany M., Galluppi, Alexander, Haines, Jessica N., Dhavale, Dhruva D., Miller, Rebecca, Choudhury, Fahim A., Sullivan, Patrick M., Cruchaga, Carlos, Perlmutter, Joel S., Ulrich, Jason D., Benitez, Bruno A., Kotzbauer, Paul T., Holtzman, David M.
Publicado no Sci Transl Med (2020)

Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes

Por Olive, Claudia, Ibanez, Laura, Farias, Fabiana H. Geraldo, Wang, Fengxian, Budde, John P., Norton, Joanne B., Gentsch, Jen, Morris, John C., Li, Zeran, Dube, Umber, Del-Aguila, Jorge, Bergmann, Kristy, Bradley, Joseph, Benitez, Bruno A., Harari, Oscar, Fagan, Anne, Ances, Beau, Cruchaga, Carlos, Fernandez, Maria Victoria
Publicado no J Alzheimers Dis (2020)

Species-Dependent Post-Transcriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex

Por Kwan, Kenneth Y., Lam, Mandy M. S., Johnson, Matthew B., Dube, Umber, Shim, Sungbo, Rašin, Mladen-Roko, Sousa, André M. M., Fertuzinhos, Sofia, Chen, Jie-Guang, Arellano, Jon I., Chan, Daniel W., Pletikos, Mihovil, Vasung, Lana, Rowitch, David H., Huang, Eric J., Schwartz, Michael L., Willemsen, Rob, Oostra, Ben A., Rakic, Pasko, Heffer, Marija, Kostović, Ivica, Judaš, Milos, Šestan, Nenad
Publicado em 2012

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Por Dube, Umber, Del-Aguila, Jorge L, Li, Zeran, Budde, John P, Jiang, Shan, Hsu, Simon, Ibanez, Laura, Fernandez, Maria Victoria, Farias, Fabiana, Norton, Joanne, Gentsch, Jen, Wang, Fengxian, Salloway, Stephen, Masters, Colin L, Lee, Jae-Hong, Graff-Radford, Neill R, Chhatwal, Jasmeer P, Bateman, Randall J, Morris, John C, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos
Publicado no Nat Neurosci (2019)

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Por Li, Zeran, Farias, Fabiana G., Dube, Umber, Del-Aguila, Jorge L., Mihindukulasuriya, Kathie A., Fernandez, Maria Victoria, Ibanez, Laura, Budde, John P., Wang, Fengxian, Lake, Allison M., Deming, Yuetiva, Perez, James, Yang, Chengran, Bahena, Jorge A., Qin, Wei, Bradley, Joseph L., Davenport, Richard, Bergmann, Kristy, Morris, John C., Perrin, Richard J., Benitez, Bruno A., Dougherty, Joseph D., Harari, Oscar, Cruchaga, Carlos
Publicado no Acta Neuropathol (2019)

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Por Ibanez, Laura, Bahena, Jorge A., Yang, Chengran, Dube, Umber, Farias, Fabiana H. G., Budde, John P., Bergmann, Kristy, Brenner-Webster, Carol, Morris, John C., Perrin, Richard J., Cairns, Nigel J., O’Donnell, John, Álvarez, Ignacio, Diez-Fairen, Monica, Aguilar, Miquel, Miller, Rebecca, Davis, Albert A., Pastor, Pau, Kotzbauer, Paul, Campbell, Meghan C., Perlmutter, Joel S., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos, Benitez, Bruno A.
Publicado no Acta Neuropathol Commun (2020)

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer disease risk

Por Deming, Yuetiva, Filipello, Fabia, Cignarella, Francesca, Cantoni, Claudia, Hsu, Simon, Mikesell, Robert, Li, Zeran, Del-Aguila, Jorge L, Dube, Umber, Farias, Fabiana Geraldo, Bradley, Joseph, Budde, John, Ibanez, Laura, Fernandez, Maria Victoria, Blennow, Kaj, Zetterberg, Henrik, Heslegrave, Amanda, Johansson, Per M, Svensson, Johan, Nellgård, Bengt, Lleo, Alberto, Alcolea, Daniel, Clarimon, Jordi, Rami, Lorena, Molinuevo, José Luis, Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Ewers, Michael, Harari, Oscar, Haass, Christian, Brett, Thomas J, Benitez, Bruno A., Karch, Celeste M., Piccio, Laura, Cruchaga, Carlos
Publicado no Sci Transl Med (2019)