Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

BACKGROUND: The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Polygenic risk scores (PRS) ma...

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Detalhes bibliográficos
Publicado no:BMC Neurol
Main Authors: Ibanez, Laura, Dube, Umber, Saef, Benjamin, Budde, John, Black, Kathleen, Medvedeva, Alexandra, Del-Aguila, Jorge L., Davis, Albert A., Perlmutter, Joel S., Harari, Oscar, Benitez, Bruno A., Cruchaga, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688622/
https://ncbi.nlm.nih.gov/pubmed/29141588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-017-0978-z
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