Polygenic risk score of sporadic late-onset Alzheimer’s disease reveals a shared architecture with the familial and early-onset forms

OBJECTIVE: To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer’s Disease (sLOAD), familial late-onset AD (fLOAD), sporadic earlyonset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). METHODS: Polygenic risk scores (PRSs) were const...

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Publicado en:Alzheimers Dement
Main Authors: Cruchaga, Carlos, Del-Aguila, Jorge L., Saef, Benjamin, Black, Kathleen, Fernandez, Maria Victoria, Budde, John, Ibanez, Laura, Kapoor, Manav, Tosto, Giuseppe, Mayeux, Richard P., Holtzman, David M., Fagan, Anne M., Morris, John C., Bateman, Randall J., Goate, Alison M., Harari, Oscar
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803427/
https://ncbi.nlm.nih.gov/pubmed/28943286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2017.08.013
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