Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

BACKGROUND: Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. METHODS: We developed and...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Li, Zeran, Del-Aguila, Jorge L., Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J., Dougherty, Joseph D., Lee, Jin-Moo, Morris, John C., Bateman, Randall J., Karch, Celeste M., Cruchaga, Carlos, Harari, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992755/
https://ncbi.nlm.nih.gov/pubmed/29880032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0551-4
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