Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

BACKGROUND: Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. METHODS: We developed and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Li, Zeran, Del-Aguila, Jorge L., Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J., Dougherty, Joseph D., Lee, Jin-Moo, Morris, John C., Bateman, Randall J., Karch, Celeste M., Cruchaga, Carlos, Harari, Oscar
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992755/
https://ncbi.nlm.nih.gov/pubmed/29880032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0551-4
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