An Antibody-Recruiting Small Molecule That Targets HIV gp120

Por Parker, Christopher G., Domaoal, Robert A., Anderson, Karen S., Spiegel, David A.
Publicado em 2009

Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

Por Lenzi, Gina M, Domaoal, Robert A, Kim, Dong-Hyun, Schinazi, Raymond F, Kim, Baek
Publicado no Retrovirology (2014)

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

Por Lenzi, Gina M., Domaoal, Robert A., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Publicado no J Biol Chem (2015)

Identification of a β(3)-Peptide HIV Fusion Inhibitor with Improved Potency in Live Cells

Por Bautista, Arjel D., Stephens, Olen M., Wang, Ligong, Domaoal, Robert A., Anderson, Karen S., Schepartz, Alanna
Publicado em 2009

Quasi-Biomimetic Ring Contraction Catalyzed by a Cysteine-Based Nucleophile: Total Synthesis of Sch-642305, Some Analogs and their Putative anti-HIV Activities

Por Dermenci, Alpay, Selig, Philipp S., Domaoal, Robert A., Spasov, Krasimir A., Anderson, Karen S., Miller, Scott J.
Publicado em 2011

Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

Por Jorgensen, William L., Bollini, Mariela, Thakur, Vinay V., Domaoal, Robert A., Spasov, Krasimir A., Anderson, Karen S.
Publicado em 2011

Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase

Por Ekkati, Anil R., Bollini, Mariela, Domaoal, Robert A., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Publicado em 2012

Discovery of Wild-type and Y181C Mutant Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors Using Virtual Screening with Multiple Protein Structures

Por Nichols, Sara E., Domaoal, Robert A., Thakur, Vinay V., Tirado-Rives, Julian, Anderson, Karen S., Jorgensen, William L.
Publicado em 2009

Pre-steady State Kinetic Analysis of HIV-1 Reverse Transcriptase for Non-canonical Ribonucleoside Triphosphate Incorporation and DNA Synthesis from Ribonucleoside-containing DNA Te...

Por Nguyen, Laura A., Domaoal, Robert A., Kennedy, Edward M., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Publicado no Antiviral Res (2014)

K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies

Por Garforth, Scott J., Domaoal, Robert A., Lwatula, Chisanga, Landau, Mark J., Meyer, Amanda J., Anderson, Karen S., Prasad, Vinayaka R.
Publicado em 2010

Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents

Por Bollini, Mariela, Domaoal, Robert A., Thakur, Vinay V., Gallardo-Macias, Ricardo, Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Publicado em 2011

From Docking False-Positive to Active Anti-HIV Agent

Por Barreiro, Gabriela, Kim, Joseph T., Guimarães, Cristiano R. W., Bailey, Christopher M., Domaoal, Robert A., Wang, Ligong, Anderson, Karen S., Jorgensen, William L.
Publicado em 2007

Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives

Por Leung, Cheryl S., Zeevaart, Jacob G., Domaoal, Robert A., Bollini, Mariela, Thakur, Vinay V., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Publicado em 2010

Optimization of Azoles as Anti-Human Immunodeficiency Virus Agents Guided by Free-Energy Calculations

Por Zeevaart, Jacob G., Wang, Ligong, Thakur, Vinay V., Leung, Cheryl S., Tirado-Rives, Julian, Bailey, Christopher M., Domaoal, Robert A., Anderson, Karen S., Jorgensen, William L.
Publicado em 2008

Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

Por Stanton, Richard A., Lu, Xiao, Detorio, Mervi, Montero, Catherine, Hammond, Emily T., Ehteshami, Maryam, Domaoal, Robert A., Nettles, James H., Feraud, Michel, Schinazi, Raymond F.
Publicado no Bioorg Med Chem Lett (2016)

Pre-steady-state Kinetic Studies Establish Entecavir 5′-Triphosphate as a Substrate for HIV-1 Reverse Transcriptase

Por Domaoal, Robert A., McMahon, Moira, Thio, Chloe L., Bailey, Christopher M., Tirado-Rives, Julian, Obikhod, Aleksander, Detorio, Mervi, Rapp, Kimberly L., Siliciano, Robert F., Schinazi, Raymond F., Anderson, Karen S.
Publicado no J Biol Chem (2007)

Illuminating HIV gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules

Por Parker, Christopher G., Dahlgren, Markus K., Tao, Ran N., Li, Don T., Douglass, Eugene F., Shoda, Takuji, Jawanda, Navneet, Spasov, Krasimir A., Lee, Sangil, Zhou, Nannan, Domaoal, Robert A., Sutton, Richard E., Anderson, Karen S., Jorgensen, William L., Krystal, Mark, Spiegel, David A.
Publicado em 2014

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Por Ehteshami, Maryam, Tao, Sijia, Ozturk, Tugba, Zhou, Longhu, Cho, Jong Hyun, Zhang, Hongwang, Amiralaei, Sheida, Shelton, Jadd R., Lu, Xiao, Khalil, Ahmed, Domaoal, Robert A., Stanton, Richard A., Suesserman, Justin E., Lin, Biing, Lee, Sam S., Amblard, Franck, Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Publicado no Antimicrob Agents Chemother (2016)

Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Por Mengshetti, Seema, Zhou, Longhu, Sari, Ozkan, De Schutter, Coralie, Zhang, Hongwang, Cho, Jong Hyun, Tao, Sijia, Bassit, Leda C., Verma, Kiran, Domaoal, Robert A., Ehteshami, Maryam, Jiang, Yong, Ovadia, Reuben, Kasthuri, Mahesh, Russell, Olivia Ollinger, McBrayer, Tamara, Whitaker, Tony, Pattassery, Judy, Pascual, Maria Luz, Uher, Lothar, Lin, Biing Y., Lee, Sam, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Publicado no J Med Chem (2019)