Pre-steady State Kinetic Analysis of HIV-1 Reverse Transcriptase for Non-canonical Ribonucleoside Triphosphate Incorporation and DNA Synthesis from Ribonucleoside-containing DNA Template

Non-dividing macrophages maintain extremely low cellular deoxyribonucleotide triphosphate (dNTP) levels, but high ribonucleotide triphosphate (rNTP) concentrations. The disparate nucleotide pools kinetically forces Human Immunodeficiency Virus 1 (HIV-1) reverse transcriptase (RT) to incorporate non-...

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Bibliographic Details
Published in:Antiviral Res
Main Authors: Nguyen, Laura A., Domaoal, Robert A., Kennedy, Edward M., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323949/
https://ncbi.nlm.nih.gov/pubmed/25557601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.12.016
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