Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

We biochemically simulated HIV-1 DNA polymerization in physiological nucleotide pools found in two HIV-1 target cell types: terminally differentiated/non-dividing macrophages and activated/dividing CD4(+) T cells. Quantitative tandem mass spectrometry shows that macrophages harbor 22–320-fold lower...

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Detalhes bibliográficos
Main Authors: Kennedy, Edward M., Gavegnano, Christina, Nguyen, Laura, Slater, Rebecca, Lucas, Amanda, Fromentin, Emilie, Schinazi, Raymond F., Kim, Baek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998149/
https://ncbi.nlm.nih.gov/pubmed/20924117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178582
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