Biochemical Studies on the Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to 1-(β-d-Dioxolane)Thymine Triphosphate

A large panel of drug-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase (RT) was used to study the mechanisms of resistance to 1-(β-d-dioxolane)thymine triphosphate (DOT-TP) and other nucleotide analogs. RT containing thymidine analog-associated mutations (TAM) or RT wit...

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Detalles Bibliográficos
Main Authors: Lennerstrand, Johan, Chu, Chung K., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891359/
https://ncbi.nlm.nih.gov/pubmed/17403997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00119-07
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