Substrate inhibition of the human immunodeficiency virus type 1 reverse transcriptase.

Substrate inhibition was observed with the heterodimeric (p66/p51) and the homodimeric (p66/p66, p51/p51) forms of human immunodeficiency virus type 1 reverse transcriptase (RNA-dependent DNA polymerase, EC 2.7.7.49). An apparent Ki value of 195 +/- 37 microM was determined for dTTP using the bacter...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Furman, P A, Painter, G, Wilson, J E, Cheng, N, Hopkins, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6013
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