Substrate inhibition of the human immunodeficiency virus type 1 reverse transcriptase.

Substrate inhibition was observed with the heterodimeric (p66/p51) and the homodimeric (p66/p66, p51/p51) forms of human immunodeficiency virus type 1 reverse transcriptase (RNA-dependent DNA polymerase, EC 2.7.7.49). An apparent Ki value of 195 +/- 37 microM was determined for dTTP using the bacter...

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Bibliographic Details
Main Authors: Furman, P A, Painter, G, Wilson, J E, Cheng, N, Hopkins, S
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC52012/
https://ncbi.nlm.nih.gov/pubmed/1712479
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