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Inhibition of the integrases of human immunodeficiency viruses type 1 and type 2 by reverse transcriptases.

We present evidence that the integrases (INs) of HIV types 1 and 2 are inhibited in vitro by the reverse transcriptases (RTs) of HIV-1, HIV-2 and murine leukaemia virus. Both 3'-end processing and 3'-end joining (strand transfer) activities of IN were affected by the RTs. Full inhibitions...

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Détails bibliographiques
Auteurs principaux: Oz, Iris, Avidan, Orna, Hizi, Amnon
Format: Artigo
Langue:Inglês
Publié: 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222338/
https://ncbi.nlm.nih.gov/pubmed/11802785
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