Illuminating HIV gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules

Here we report on the structure-based optimization of antibody-recruiting molecules targeting HIV gp120 (ARM-H). These studies have leveraged a combination of medicinal chemistry, biochemical and cellular assay analysis, and computation. Our findings have afforded an optimized analog of ARM-H, which...

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Detalhes bibliográficos
Main Authors: Parker, Christopher G., Dahlgren, Markus K., Tao, Ran N., Li, Don T., Douglass, Eugene F., Shoda, Takuji, Jawanda, Navneet, Spasov, Krasimir A., Lee, Sangil, Zhou, Nannan, Domaoal, Robert A., Sutton, Richard E., Anderson, Karen S., Jorgensen, William L., Krystal, Mark, Spiegel, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217211/
https://ncbi.nlm.nih.gov/pubmed/25379167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4SC00484A
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