Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

Non-nucleoside inhibitors of HIV reverse transcriptase (NNRTIs) are being pursued with guidance from molecular modeling including free energy perturbation (FEP) calculations for protein-inhibitor binding affinities. The previously reported pyrimidinylphenylamine 1 and its chloro analog 2 are potent...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Jorgensen, William L., Bollini, Mariela, Thakur, Vinay V., Domaoal, Robert A., Spasov, Krasimir A., Anderson, Karen S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183387/
https://ncbi.nlm.nih.gov/pubmed/21853995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2058583
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk