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Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

Non-nucleoside inhibitors of HIV reverse transcriptase (NNRTIs) are being pursued with guidance from molecular modeling including free energy perturbation (FEP) calculations for protein-inhibitor binding affinities. The previously reported pyrimidinylphenylamine 1 and its chloro analog 2 are potent...

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Main Authors: Jorgensen, William L., Bollini, Mariela, Thakur, Vinay V., Domaoal, Robert A., Spasov, Krasimir A., Anderson, Karen S.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183387/
https://ncbi.nlm.nih.gov/pubmed/21853995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2058583
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