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Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with computational guidance. Extension of azine-containing inhibitors into the entrance channel between Lys103 and Glu138 has led to the discovery of potent and structurally novel derivatives including dimeric inhibi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278212/ https://ncbi.nlm.nih.gov/pubmed/22269110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.132 |
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