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Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group
Members of the catechol diether class are highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). The most active compounds yield EC(50) values below 0.5 nM in assays using human T-cells infected by wild-type HIV-1. However, these compounds like rilpivirine, the most recentl...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877923/ https://ncbi.nlm.nih.gov/pubmed/24151856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408917n |
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