Extension into the entrance channel of HIV-1 reverse transcriptase – crystallography and enhanced solubility

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that feature extension into the entrance channel near Glu138. Complexes of the parent anilinylpyrimidine 1 and the morpholinoethoxy analog 2j with HIV-RT have received crystallographic characterization confirming the desi...

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Détails bibliographiques
Auteurs principaux: Bollini, Mariela, Frey, Kathleen M., Cisneros, José A., Spasov, Krasimir A., Das, Kalyan, Bauman, Joseph D., Arnold, Eddy, Anderson, Karen S., Jorgensen, William L.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761378/
https://ncbi.nlm.nih.gov/pubmed/23899617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.093
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