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Extension into the entrance channel of HIV-1 reverse transcriptase – crystallography and enhanced solubility
Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that feature extension into the entrance channel near Glu138. Complexes of the parent anilinylpyrimidine 1 and the morpholinoethoxy analog 2j with HIV-RT have received crystallographic characterization confirming the desi...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3761378/ https://ncbi.nlm.nih.gov/pubmed/23899617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.093 |
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