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Identification of a β(3)-Peptide HIV Fusion Inhibitor with Improved Potency in Live Cells

We recently reported a β3-decapeptide, βWWI-1, that binds a validated gp41 model in vitro and inhibits gp41-mediated fusion in cell culture. Here we report six analogs of βWWI-1 containing a variety of non-natural side chains in place of the central tryptophan of the WWI-epitope. These analogs were...

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Detalhes bibliográficos
Main Authors: Bautista, Arjel D., Stephens, Olen M., Wang, Ligong, Domaoal, Robert A., Anderson, Karen S., Schepartz, Alanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737262/
https://ncbi.nlm.nih.gov/pubmed/19497744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.032
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