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Identification of a β(3)-Peptide HIV Fusion Inhibitor with Improved Potency in Live Cells
We recently reported a β3-decapeptide, βWWI-1, that binds a validated gp41 model in vitro and inhibits gp41-mediated fusion in cell culture. Here we report six analogs of βWWI-1 containing a variety of non-natural side chains in place of the central tryptophan of the WWI-epitope. These analogs were...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737262/ https://ncbi.nlm.nih.gov/pubmed/19497744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.032 |
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