Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer

Autor Balog, Aaron, Rampulla, Richard, Martin, Gregory S., Krystek, Stanley R., Attar, Ricardo, Dell-John, Janet, DiMarco, John D., Fairfax, David, Gougoutas, Jack, Holst, Christian L., Nation, Andrew, Rizzo, Cheryl, Rossiter, Lana M., Schweizer, Liang, Shan, Weifang, Spergel, Steven, Spires, Thomas, Cornelius, Georgia, Gottardis, Marco, Trainor, George, Vite, Gregory D., Salvati, Mark E.
Vydáno v ACS Med Chem Lett (2015)

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

Autor Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wang, Chunlei, Zhang, Yingru, Schmidt, Robert J., Wei, Donna D., Miller, Michael M., Allen, Martin P., Li, Ling, Carter, Percy H., Vite, Gregory D., Borzilleri, Robert M.
Vydáno v ACS Med Chem Lett (2015)

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P(1)) Modulators: Optimization of the PK, PD, and Safety Profiles

Autor Xiao, Zili, Yang, Michael G., Dhar, T. G. Murali, Xiao, Hai-Yun, Gilmore, John L., Marcoux, David, McIntyre, Kim W., Taylor, Tracy L., Shi, Hong, Levesque, Paul C., Marino, Anthony M., Cornelius, Georgia, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Lehman-McKeeman, Lois D., Sun, Huadong, Xie, Jenny H., Carter, Percy H., Dyckman, Alaric J.
Vydáno v ACS Med Chem Lett (2020)

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

Autor Liu, Qingjie, Batt, Douglas G., Weigelt, Carolyn A., Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Wang, Jinhong, Yarde, Melissa, Li, Sha, Shuster, David J., Xie, Jenny H., Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Khandelwal, Purnima, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Dhar, T. G. Murali
Vydáno v ACS Med Chem Lett (2020)

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P(1) Receptor Modulator in Clinical Trials

Autor Dhar, T. G. Murali, Xiao, Hai-Yun, Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Warrack, Bethanne, Shi, Hong, Levesque, Paul C., Zhu, Jia L., Hennan, James, Balimane, Praveen, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D’Arienzo, Celia J., Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Dyckman, Alaric J.
Vydáno v ACS Med Chem Lett (2016)

Identification of potent tricyclic prodrug S1P(1) receptor modulators

Autor Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G., Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Shi, Hong, Levesque, Paul C., Sun, Huadong, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D'Arienzo, Celia J., Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Dyckman, Alaric J.
Vydáno v Medchemcomm (2016)

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Autor Cherney, Robert J., Cornelius, Lyndon A. M., Srivastava, Anurag, Weigelt, Carolyn A., Marcoux, David, Duan, James J.-W., Shi, Qing, Batt, Douglas G., Liu, Qingjie, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John, Khan, Javed, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Mathur, Arvind, Li, Sha, Shuster, David, Khandelwal, Purnima, Borowski, Virna, Xie, Jenny, Obermeier, Mary, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Tino, Joseph A., Macor, John E., Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H., Dhar, T. G. Murali
Vydáno v ACS Med Chem Lett (2020)

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis

Autor Liu, Qingjie, Xiao, Hai-Yun, Batt, Douglas G., Xiao, Zili, Zhu, Yeheng, Yang, Michael G., Li, Ning, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Weigelt, Carolyn A., Wang, Jinhong, Li, Sha, Shuster, David J., Xie, Jenny H., Song, Yunling, Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Chacko, Silvi, Khandelwal, Purnima, Dudhgaonkar, Shailesh, Rudra, Anjuman, Nagar, Jignesh, Murali, Venkata, Govindarajan, Arun, Denton, Rex, Zhao, Qihong, Meanwell, Nicholas A., Borzilleri, Robert, Dhar, T. G. Murali
Vydáno v ACS Med Chem Lett (2021)