Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Por Yoon, Miyoung, Clewell, Harvey J.
Publicado no Toxicol Res (2016)

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.

Por Clewell, Harvey J, Andersen, Melvin E, Barton, Hugh A
Publicado em 2002

Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment

Por Tan, Yu-Mei, Clewell, Harvey, Campbell, Jerry, Andersen, Melvin
Publicado em 2011

Case Study Approaches for Implementing the 2007 NRC Report “Toxicity Testing in the 21(st) Century: A Vision and A Strategy”

Por Andersen, Melvin E., Clewell, Harvey J., Carmichael, Paul L., Boekelheide, Kim
Publicado em 2011

Prenatal PCB-153 Exposure and Decreased Birth Weight: Verner et al. Respond

Por Verner, Marc-André, Andersen, Melvin E., Clewell, Harvey J., Longnecker, Matthew P.
Publicado em 2014

Letter to the editor re: Cheng, YH., Chou, WC., Yang, YF. et al. Environ Sci Pollut Res (2017). https://doi.org/10.1007/s11356-017-0875-4

Por Travis, Kim Z, Clewell, Harvey J, Campbell, Jerry L, Hinderliter, Paul M
Publicado no Environ Sci Pollut Res Int (2018)

Development of PBPK Models for PFOA and PFOS for Human Pregnancy and Lactation Life Stages

Por Loccisano, Anne E., Longnecker, Matthew P., Campbell, Jerry L., Andersen, Melvin E., Clewell, Harvey J.
Publicado em 2013

Hormesis and Adaptive Cellular Control Systems

Por Zhang, Qiang, Pi, Jingbo, Woods, Courtney G., Jarabek, Annie M., Clewell, Harvey J., Andersen, Melvin E.
Publicado em 2008

Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses

Por Zhang, Qiang, Bhattacharya, Sudin, Conolly, Rory B., Clewell, Harvey J., Kaminski, Norbert E., Andersen, Melvin E.
Publicado no Environ Health Perspect (2014)

High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling

Por Strope, Cory L., Mansouri, Kamel, Clewell, Harvey J., Rabinowitz, James R., Stevens, Caroline, Wambaugh, John F.
Publicado no Sci Total Environ (2017)

Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

Por Verner, Marc-André, McDougall, Robin, Glynn, Anders, Andersen, Melvin E., Clewell, Harvey J., Longnecker, Matthew P.
Publicado em 2013

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water

Por Breckenridge, Charles B., Campbell, Jerry L., Clewell, Harvey J., Andersen, Melvin E., Valdez-Flores, Ciriaco, Sielken, Robert L.
Publicado no Toxicol Sci (2016)

Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling

Por Campbell, Jerry, Franzen, Allison, Van Landingham, Cynthia, Lumpkin, Michael, Crowell, Susan, Meredith, Clive, Loccisano, Anne, Gentry, Robinan, Clewell, Harvey
Publicado no Inhal Toxicol (2016)

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

Por Taylor, Michael D., Clewell, Harvey J., Andersen, Melvin E., Schroeter, Jeffry D., Yoon, Miyoung, Keene, Athena M., Dorman, David C.
Publicado em 2012

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Por Chiu, Weihsueh A., Campbell, Jerry L., Clewell, Harvey J., Zhou, Yi-Hui, Wright, Fred A., Guyton, Kathryn Z., Rusyn, Ivan
Publicado em 2014

Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action

Por Bogen, Kenneth T., Benson, Janet M., Yost, Garold S., Morris, John B., Dahl, Alan R., Clewell, Harvey J., Krishnan, Kannan, Omiecinski, Curtis J.
Publicado em 2007

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human

Por Campbell, Jerry L., Andersen, Melvin E., Hinderliter, Paul M., Yi, Kun Don, Pastoor, Timothy P., Breckenridge, Charles B., Clewell, Harvey J.
Publicado no Toxicol Sci (2016)

Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies

Por Pedersen, Jenny M., Shim, Yoo-Sik, Hans, Vaibhav, Phillips, Martin B., Macdonald, Jeffrey M., Walker, Glenn, Andersen, Melvin E., Clewell, Harvey J., Yoon, Miyoung
Publicado no Front Bioeng Biotechnol (2016)

Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates

Por Moreau, Marjory, Leonard, Jeremy, Phillips, Katherine A., Campbell, Jerry, Pendse, Salil N., Nicolas, Chantel, Phillips, Martin, Yoon, Miyoung, Tan, Yu-Mei, Smith, Sherrie, Pudukodu, Harish, Isaacs, Kristin, Clewell, Harvey
Publicado no Chemosphere (2017)

A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

Por Yan, Grace Zhixia, Generaux, Claudia N., Yoon, Miyoung, Goldsmith, Rachel B., Tidwell, Richard R., Hall, James E., Olson, Carol A., Clewell, Harvey J., Brouwer, Kim L. R., Paine, Mary F.
Publicado em 2012