Invited Perspective: Prioritizing Chemical Testing and Evaluation Using Validated in Vitro Assays Relevant to Key Characteristics

le Guyton, Kathryn Z., Schubauer-Berigan, Mary K.
Foilsithe in Environ Health Perspect (2021)

Approaches to Human Health Risk Assessment Based on the Signal-To-Noise Crossover Dose

le Chiu, Weihsueh A., Guyton, Kathryn Z., Hogan, Karen, Jinot, Jennifer
Foilsithe 2012

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review

le Chappell, Grace, Pogribny, Igor P., Guyton, Kathryn Z., Rusyn, Ivan
Foilsithe in Mutat Res Rev Mutat Res (2016)

Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides

le Guha, Neela, Guyton, Kathryn Z., Loomis, Dana, Barupal, Dinesh Kumar
Foilsithe in Environ Health Perspect (2016)

Classification schemes for carcinogenicity based on hazard identification serve science and society

le Loomis, Dana, Guyton, Kathryn Z., Straif, Kurt, Wild, Christopher P.
Foilsithe in Regul Toxicol Pharmacol (2017)

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data

le Rusyn, Ivan, Sedykh, Alexander, Low, Yen, Guyton, Kathryn Z., Tropsha, Alexander
Foilsithe 2012

Trichloroethylene Biotransformation and its Role in Mutagenicity, Carcinogenicity and Target Organ Toxicity

le Lash, Lawrence H., Chiu, Weihsueh A., Guyton, Kathryn Z., Rusyn, Ivan
Foilsithe in Mutat Res Rev Mutat Res (2014)

Key Characteristics Approach to Carcinogenic Hazard Identification

le Guyton, Kathryn Z., Rieswijk, Linda, Wang, Amy, Chiu, Weihsueh A., Smith, Martyn T.
Foilsithe in Chem Res Toxicol (2018)

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

le Chiu, Weihsueh A., Guyton, Kathryn Z., Martin, Matthew T., Reif, David M., Rusyn, Ivan
Foilsithe in ALTEX (2017)

Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals

le Zeise, Lauren, Bois, Frederic Y., Chiu, Weihsueh A., Hattis, Dale, Rusyn, Ivan, Guyton, Kathryn Z.
Foilsithe 2012

Trichloroethylene: Mechanistic, Epidemiologic and Other Supporting Evidence of Carcinogenic Hazard

le Rusyn, Ivan, Chiu, Weihsueh A., Lash, Lawrence H., Kromhout, Hans, Hansen, Johnni, Guyton, Kathryn Z.
Foilsithe 2013

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

le Cichocki, Joseph A., Guyton, Kathryn Z., Guha, Neela, Chiu, Weihsueh A., Rusyn, Ivan, Lash, Lawrence H.
Foilsithe in J Pharmacol Exp Ther (2016)

A systematic approach for identifying and presenting mechanistic evidence in human health assessments

le Kushman, Mary E., Kraft, Andrew D., Guyton, Kathryn Z., Chiu, Weihsueh A., Makris, Susan L., Rusyn, Ivan
Foilsithe 2013

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

le Corvi, Raffaella, Madia, Federica, Guyton, Kathryn Z., Kasper, Peter, Rudel, Ruthann, Colacci, Annamaria, Kleinjans, Jos, Jennings, Paul
Foilsithe in Toxicol In Vitro (2017)

Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals

le Wignall, Jessica A., Muratov, Eugene, Sedykh, Alexander, Guyton, Kathryn Z., Tropsha, Alexander, Rusyn, Ivan, Chiu, Weihsueh A.
Foilsithe in Environ Health Perspect (2018)

A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants

le Guyton, Kathryn Z., Chiu, Weihsueh A., Bateson, Thomas F., Jinot, Jennifer, Scott, Cheryl Siegel, Brown, Rebecca C., Caldwell, Jane C.
Foilsithe 2009

Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments

le Wignall, Jessica A., Shapiro, Andrew J., Wright, Fred A., Woodruff, Tracey J., Chiu, Weihsueh A., Guyton, Kathryn Z., Rusyn, Ivan
Foilsithe 2014

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

le Chiu, Weihsueh A., Campbell, Jerry L., Clewell, Harvey J., Zhou, Yi-Hui, Wright, Fred A., Guyton, Kathryn Z., Rusyn, Ivan
Foilsithe 2014

Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans()

le Parham, Fred, Wise, Amber, Axelrad, Daniel A., Guyton, Kathryn Z., Portier, Christopher, Zeise, Lauren, Zoeller, R. Thomas, Woodruff, Tracey J.
Foilsithe in Environ Res (2012)

Application of the key characteristics of carcinogens in cancer hazard identification

le Guyton, Kathryn Z, Rusyn, Ivan, Chiu, Weihsueh A, Corpet, Denis E, van den Berg, Martin, Ross, Matthew K, Christiani, David C, Beland, Frederick A, Smith, Martyn T
Foilsithe in Carcinogenesis (2018)