Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Background: Quantitative estimation of toxicokinetic variability in the human population is a persistent challenge in risk assessment of environmental chemicals. Traditionally, interindividual differences in the population are accounted for by default assumptions or, in rare cases, are based on huma...

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Main Authors: Chiu, Weihsueh A., Campbell, Jerry L., Clewell, Harvey J., Zhou, Yi-Hui, Wright, Fred A., Guyton, Kathryn Z., Rusyn, Ivan
Formáid: Artigo
Teanga:Inglês
Foilsithe: NLM-Export 2014
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014769/
https://ncbi.nlm.nih.gov/pubmed/24518055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1307623
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