A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

Dose selection during antiparasitic drug development in animal models and humans traditionally has relied on correlations between plasma concentrations obtained at or below maximally tolerated doses that are efficacious. The objective of this study was to improve the understanding of the relationshi...

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Main Authors: Yan, Grace Zhixia, Generaux, Claudia N., Yoon, Miyoung, Goldsmith, Rachel B., Tidwell, Richard R., Hall, James E., Olson, Carol A., Clewell, Harvey J., Brouwer, Kim L. R., Paine, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250045/
https://ncbi.nlm.nih.gov/pubmed/21953913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.040063
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