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A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
AIMS: Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was to cha...
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| Publicado no: | Br J Clin Pharmacol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475681/ https://ncbi.nlm.nih.gov/pubmed/30761579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13902 |
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