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A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers

AIMS: Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was to cha...

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Publicado en:Br J Clin Pharmacol
Main Authors: Xie, Feifan, Vermeulen, An, Colin, Pieter, Cheng, Zeneng
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475681/
https://ncbi.nlm.nih.gov/pubmed/30761579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13902
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