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Metabolism of Piperaquine to Its Antiplasmodial Metabolites and Their Pharmacokinetic Profiles in Healthy Volunteers

As a partner antimalarial for artemisinin drug-based combination therapy (ACT), piperaquine (PQ) can be metabolized into two major metabolites, including piperaquine N-oxide (M1) and piperaquine N,N-dioxide (M2). To better understand the antimalarial potency of PQ, the antimalarial activity of the P...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Liu, Huixiang, Zhou, Hongchang, Cai, Tianyu, Yang, Aijuan, Zang, Meitong, Xing, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105796/
https://ncbi.nlm.nih.gov/pubmed/29784841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00260-18
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