Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin–piperaquine in healthy volunteers

AIMS: The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug–drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS: The population pha...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Chotsiri, Palang, Wattanakul, Thanaporn, Hoglund, Richard M., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Blessborn, Daniel, Jittamala, Podjanee, White, Nicholas J., Day, Nicholas P.J., Tarning, Joel
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Pharmacokinetic Dynamic Relationships
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698590/
https://ncbi.nlm.nih.gov/pubmed/28695570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13372
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