Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin–piperaquine in healthy volunteers

AIMS: The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug–drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS: The population pha...

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Gepubliceerd in:Br J Clin Pharmacol
Hoofdauteurs: Chotsiri, Palang, Wattanakul, Thanaporn, Hoglund, Richard M., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Blessborn, Daniel, Jittamala, Podjanee, White, Nicholas J., Day, Nicholas P.J., Tarning, Joel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
Onderwerpen:
Pharmacokinetic Dynamic Relationships
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698590/
https://ncbi.nlm.nih.gov/pubmed/28695570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13372
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