PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human

The previously-published physiologically based pharmacokinetic model for atrazine (ATZ), deisopropylatrazine (DIA), deethylatrazine (DEA), and diaminochlorotriazine (DACT), which collectively comprise the total chlorotriazines (TCT) as represented in this study, was modified to allow for scaling to...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Campbell, Jerry L., Andersen, Melvin E., Hinderliter, Paul M., Yi, Kun Don, Pastoor, Timothy P., Breckenridge, Charles B., Clewell, Harvey J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Pharmacokinetic Modeling of Atrazine and Metabolites
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809456/
https://ncbi.nlm.nih.gov/pubmed/26794140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw014
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