Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies

Accurate prediction of metabolism is a significant outstanding challenge in toxicology. The best predictions are based on experimental data from in vitro systems using primary hepatocytes. The predictivity of the primary hepatocyte-based culture systems, however, is still limited due to well-known p...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Pedersen, Jenny M., Shim, Yoo-Sik, Hans, Vaibhav, Phillips, Martin B., Macdonald, Jeffrey M., Walker, Glenn, Andersen, Melvin E., Clewell, Harvey J., Yoon, Miyoung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044513/
https://ncbi.nlm.nih.gov/pubmed/27747210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2016.00072
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