G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

Por Daniel, James T., Clark, Richard J.
Publicado no Toxins (Basel) (2017)

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design

Por Clark, Richard J., Daly, Norelle L., Craik, David J.
Publicado em 2006

Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif

Por Daly, Norelle L., Clark, Richard J., Plan, Manuel R., Craik, David J.
Publicado em 2006

Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist

Por Kompella, Shiva N., Hung, Andrew, Clark, Richard J., Marí, Frank, Adams, David J.
Publicado no J Biol Chem (2015)

Differential Ca(v)2.1 and Ca(v)2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABA(B) receptor activation

Por Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J., Adams, David J.
Publicado em 2014

Lysine-scanning Mutagenesis Reveals an Amendable Face of the Cyclotide Kalata B1 for the Optimization of Nematocidal Activity

Por Huang, Yen-Hua, Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C., Craik, David J.
Publicado em 2010

Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor

Por Halai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J., Craik, David J.
Publicado em 2009

Structure and Activity of α-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABA(B) Receptor-coupled N-type Calcium Channels

Por Daly, Norelle L., Callaghan, Brid, Clark, Richard J., Nevin, Simon T., Adams, David J., Craik, David J.
Publicado em 2011

Understanding the Structure/Activity Relationships of the Iron Regulatory Peptide Hepcidin

Por Clark, Richard J., Tan, Chia Chia, Preza, Gloria C., Nemeth, Elizabeta, Ganz, Tomas, Craik, David J.
Publicado em 2011

Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum

Por Hellinger, Roland, Koehbach, Johannes, Puigpinós, Albert, Clark, Richard J., Tarragó, Teresa, Giralt, Ernest, Gruber, Christian W.
Publicado no J Nat Prod (2015)

Helminth Immunomodulation in Autoimmune Disease

Por Smallwood, Taylor B., Giacomin, Paul R., Loukas, Alex, Mulvenna, Jason P., Clark, Richard J., Miles, John J.
Publicado no Front Immunol (2017)

Rational Design of α-Conotoxin Analogues Targeting α7 Nicotinic Acetylcholine Receptors: IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Por Armishaw, Christopher, Jensen, Anders A., Balle, Thomas, Clark, Richard J., Harpsøe, Kasper, Skonberg, Christian, Liljefors, Tommy, Strømgaard, Kristian
Publicado em 2009

CHEMICAL RE-ENGINEERING OF CHLOROTOXIN IMPROVES BIOCONJUGATION PROPERTIES FOR TUMOR IMAGING AND TARGETED THERAPY

Por Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J., Olson, James M.
Publicado em 2011

A Synthetic Combinatorial Strategy for Developing α-Conotoxin Analogs as Potent α(7) Nicotinic Acetylcholine Receptor Antagonists

Por Armishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A., Jensen, Anders A.
Publicado em 2010

Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors

Por Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J., Adams, David J.
Publicado em 2013

Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII

Por Clark, Richard J., Fischer, Harald, Dempster, Louise, Daly, Norelle L., Rosengren, K. Johan, Nevin, Simon T., Meunier, Frederic A., Adams, David J., Craik, David J.
Publicado em 2005

Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics

Por Jin, Ai-Hua, Brandstaetter, Hemma, Nevin, Simon T, Tan, Chia Chia, Clark, Richard J, Adams, David J, Alewood, Paul F, Craik, David J, Daly, Norelle L
Publicado em 2007

Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

Por Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala, Noakes, Peter G.
Publicado no Sci Rep (2016)

Novel Inhibitor Cystine Knot Peptides from Momordica charantia

Por He, Wen-Jun, Chan, Lai Yue, Clark, Richard J., Tang, Jun, Zeng, Guang-Zhi, Franco, Octavio L., Cantacessi, Cinzia, Craik, David J., Daly, Norelle L., Tan, Ning-Hua
Publicado em 2013