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Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor

Vc1.1 is a disulfide-rich peptide inhibitor of nicotinic acetylcholine receptors that has stimulated considerable interest in these receptors as potential therapeutic targets for the treatment of neuropathic pain. Here we present an extensive series of mutational studies in which all residues except...

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Bibliografski detalji
Glavni autori: Halai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J., Craik, David J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740453/
https://ncbi.nlm.nih.gov/pubmed/19447885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015339
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