Structure based drug design and in vitro metabolism study: discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent

av Xiang, Weiguo, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
I publikationen Bioorg Med Chem (2018)

Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angio...

av Pavana, Roheeth Kumar, Choudhary, Shruti, Bastian, Anja, Ihnat, Michael A., Bai, Raouli, Hamel, Ernest, Gangjee, Aleem
I publikationen Bioorg Med Chem (2016)

Optimization of the linker domain in a dimeric compound that degrades an r(CUG) repeat expansion in cells

av Benhamou, Raphael I., Abe, Masahito, Choudhary, Shruti, Meyer, Samantha M., Angelbello, Alicia J., Disney, Matthew D.
I publikationen J Med Chem (2020)

Potential of Substituted Quinazolines to Interact with Multiple Targets in the Treatment of Cancer

av Choudhary, Shruti, Doshi, Arpit, Luckett-Chastain, Lerin, Ihnat, Michael, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
I publikationen Bioorg Med Chem (2021)

Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion

av Vezina-Dawod, Simon, Angelbello, Alicia J., Choudhary, Shruti, Wang, Kye Won, Yildirim, Ilyas, Disney, Matthew D.
I publikationen ACS Med Chem Lett (2021)

Design, Synthesis, and Structure–Activity Relationships of Pyrimido[4,5-b]indole-4-amines as Microtubule Depolymerizing Agents that are Effective against Multidrug Resistant Cells...

av Devambatla, Ravi Kumar Vyas, Li, Wei, Zaware, Nilesh, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
I publikationen Bioorg Med Chem Lett (2017)

Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

av Benhamou, Raphael I, Vezina-Dawod, Simon, Choudhary, Shruti, Wang, Kye Won, Meyer, Samantha M, Yildirim, Ilyas, Disney, Matthew D
I publikationen Chembiochem (2020)

Catalytic Isonitrile Insertions and Condensations Initiated by RNC–X Complexation

av Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.
I publikationen Adv Synth Catal (2014)

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer...

av Devambatla, Ravi Kumar Vyas, Namjoshi, Ojas A., Choudhary, Shruti, Hamel, Ernest, Shaffer, Corena V., Rohena, Cristina C., Mooberry, Susan L., Gangjee, Aleem
I publikationen J Med Chem (2016)

Janus Compounds, 5-Chloro-N(4)-methyl-N(4)-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

av Rohena, Cristina C., Risinger, April L., Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F., Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L.
I publikationen Molecules (2016)

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

av Ursu, Andrei, Wang, Kye Won, Bush, Jessica A, Choudhary, Shruti, Chen, Jonathan L, Baisden, Jared T, Zhang, Yong-Jie, Gendron, Tania F, Petrucelli, Leonard, Yildirim, Ilyas, Disney, Matthew D
I publikationen ACS Chem Biol (2020)

Size-Dependent Filtration Efficiency of Alternative Facemask Filter Materials

av Dhanraj, David I. A., Choudhary, Shruti, Jammalamadaka, Udayabhanu, Ballard, David H., Kumfer, Benjamin M., Dang, Audrey J., Williams, Brent J., Meacham, Kathleen W., Axelbaum, Richard L., Biswas, Pratim
I publikationen Materials (Basel) (2021)

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

av Angelbello, Alicia J., Benhamou, Raphael I., Rzuczek, Suzanne G., Choudhary, Shruti, Tang, Zhenzhi, Chen, Jonathan L., Roy, Madhuparna, Wang, Kye Won, Yildirim, Ilyas, Jun, Albert S., Thornton, Charles A., Disney, Matthew D.
I publikationen Cell Chem Biol (2020)