Structure based drug design and in vitro metabolism study: discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent

Autor Xiang, Weiguo, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Vydáno v Bioorg Med Chem (2018)

Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angio...

Autor Pavana, Roheeth Kumar, Choudhary, Shruti, Bastian, Anja, Ihnat, Michael A., Bai, Raouli, Hamel, Ernest, Gangjee, Aleem
Vydáno v Bioorg Med Chem (2016)

Optimization of the linker domain in a dimeric compound that degrades an r(CUG) repeat expansion in cells

Autor Benhamou, Raphael I., Abe, Masahito, Choudhary, Shruti, Meyer, Samantha M., Angelbello, Alicia J., Disney, Matthew D.
Vydáno v J Med Chem (2020)

Potential of Substituted Quinazolines to Interact with Multiple Targets in the Treatment of Cancer

Autor Choudhary, Shruti, Doshi, Arpit, Luckett-Chastain, Lerin, Ihnat, Michael, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Vydáno v Bioorg Med Chem (2021)

Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion

Autor Vezina-Dawod, Simon, Angelbello, Alicia J., Choudhary, Shruti, Wang, Kye Won, Yildirim, Ilyas, Disney, Matthew D.
Vydáno v ACS Med Chem Lett (2021)

Design, Synthesis, and Structure–Activity Relationships of Pyrimido[4,5-b]indole-4-amines as Microtubule Depolymerizing Agents that are Effective against Multidrug Resistant Cells...

Autor Devambatla, Ravi Kumar Vyas, Li, Wei, Zaware, Nilesh, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Vydáno v Bioorg Med Chem Lett (2017)

Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

Autor Benhamou, Raphael I, Vezina-Dawod, Simon, Choudhary, Shruti, Wang, Kye Won, Meyer, Samantha M, Yildirim, Ilyas, Disney, Matthew D
Vydáno v Chembiochem (2020)

Catalytic Isonitrile Insertions and Condensations Initiated by RNC–X Complexation

Autor Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.
Vydáno v Adv Synth Catal (2014)

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer...

Autor Devambatla, Ravi Kumar Vyas, Namjoshi, Ojas A., Choudhary, Shruti, Hamel, Ernest, Shaffer, Corena V., Rohena, Cristina C., Mooberry, Susan L., Gangjee, Aleem
Vydáno v J Med Chem (2016)

Janus Compounds, 5-Chloro-N(4)-methyl-N(4)-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Autor Rohena, Cristina C., Risinger, April L., Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F., Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L.
Vydáno v Molecules (2016)

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

Autor Ursu, Andrei, Wang, Kye Won, Bush, Jessica A, Choudhary, Shruti, Chen, Jonathan L, Baisden, Jared T, Zhang, Yong-Jie, Gendron, Tania F, Petrucelli, Leonard, Yildirim, Ilyas, Disney, Matthew D
Vydáno v ACS Chem Biol (2020)

Size-Dependent Filtration Efficiency of Alternative Facemask Filter Materials

Autor Dhanraj, David I. A., Choudhary, Shruti, Jammalamadaka, Udayabhanu, Ballard, David H., Kumfer, Benjamin M., Dang, Audrey J., Williams, Brent J., Meacham, Kathleen W., Axelbaum, Richard L., Biswas, Pratim
Vydáno v Materials (Basel) (2021)

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

Autor Angelbello, Alicia J., Benhamou, Raphael I., Rzuczek, Suzanne G., Choudhary, Shruti, Tang, Zhenzhi, Chen, Jonathan L., Roy, Madhuparna, Wang, Kye Won, Yildirim, Ilyas, Jun, Albert S., Thornton, Charles A., Disney, Matthew D.
Vydáno v Cell Chem Biol (2020)