Prediction and validation of enzyme and transporter off-targets for metformin

Por Yee, Sook Wah, Lin, Lawrence, Merski, Matthew, Keiser, Michael J., Gupta, Aakash, Zhang, Youcai, Chien, Huan-Chieh, Shoichet, Brian K., Giacomini, Kathleen M.
Publicado no J Pharmacokinet Pharmacodyn (2015)

LAT-1 Activity of meta-Substituted Phenylalanine and Tyrosine Analogs

Por Augustyn, Evan, Finke, Karissa, Zur, Arik A., Hansen, Logan, Heeren, Nathan, Chien, Huan-Chieh, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.
Publicado no Bioorg Med Chem Lett (2016)

Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates

Por Wang, Hurng-Yi, Chien, Huan-Chieh, Osada, Naoki, Hashimoto, Katsuyuki, Sugano, Sumio, Gojobori, Takashi, Chou, Chen-Kung, Tsai, Shih-Feng, Wu, Chung-I, Shen, C.-K. James
Publicado em 2007

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Por Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M., Chen, Eugene C., Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S., Giacomini, Kathleen M.
Publicado no Mol Pharm (2015)

Targeted Disruption in Mice of a Neural Stem Cell-Maintaining, KRAB-Zn Finger-Encoding Gene That Has Rapidly Evolved in the Human Lineage

Por Chien, Huan-Chieh, Wang, Hurng-Yi, Su, Yi-Ning, Lai, Kuan-Yu, Lu, Li-Chen, Chen, Pau-Chung, Tsai, Shih-Feng, Wu, Chung-I, Hsieh, Wu-Shiun, Shen, Che-Kun James
Publicado em 2012

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

Por Zur, Arik A., Chien, Huan-Chieh, Augustyn, Evan, Flint, Andrew, Heeren, Nathan, Finke, Karissa, Hernandez, Christopher, Hansen, Logan, Miller, Sydney, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.
Publicado no Bioorg Med Chem Lett (2016)

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Por Chen, Ligong, Shu, Yan, Liang, Xiaomin, Chen, Eugene C., Yee, Sook Wah, Zur, Arik A., Li, Shuanglian, Xu, Lu, Keshari, Kayvan R., Lin, Michael J., Chien, Huan-Chieh, Zhang, Youcai, Morrissey, Kari M., Liu, Jason, Ostrem, Jonathan, Younger, Noah S., Kurhanewicz, John, Shokat, Kevan M., Ashrafi, Kaveh, Giacomini, Kathleen M.
Publicado em 2014

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Por Zhou, Kaixin, Yee, Sook Wah, Seiser, Eric L, van Leeuwen, Nienke, Tavendale, Roger, Bennett, Amanda J, Groves, Christopher J, Coleman, Ruth L, van der Heijden, Amber A, Beulens, Joline W, de Keyser, Catherine E, Zaharenko, Linda, Rotroff, Daniel M, Out, Mattijs, Jablonski, Kathleen A, Chen, Ling, Javorský, Martin, Židzik, Jozef, Levin, Albert M, Williams, L Keoki, Dujic, Tanja, Semiz, Sabina, Kubo, Michiaki, Chien, Huan-Chieh, Maeda, Shiro, Witte, John S, Wu, Longyang, Tkáč, Ivan, Kooy, Adriaan, van Schaik, Ron H N, Stehouwer, Coen D A, Logie, Lisa, Sutherland, Calum, Klovins, Janis, Pirags, Valdis, Hofman, Albert, Stricker, Bruno H, Motsinger-Reif, Alison A, Wagner, Michael J, Innocenti, Federico, 't Hart, Leen M, Holman, Rury R, McCarthy, Mark I, Hedderson, Monique M, Palmer, Colin N A, Florez, Jose C, Giacomini, Kathleen M, Pearson, Ewan R
Publicado no Nat Genet (2016)