Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH’s, metformin is transported by membrane transporters, which play major roles in its absorption and disposition. Recently, our laboratory demonstrated that org...

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Bibliographic Details
Published in:Mol Pharm
Main Authors: Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M., Chen, Eugene C., Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S., Giacomini, Kathleen M.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800991/
https://ncbi.nlm.nih.gov/pubmed/26528626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00501
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