OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Organic cation transporter 1, OCT1 (SLC22A1), is the major hepatic uptake transporter for metformin, the most prescribed antidiabetic drug. However, its endogenous role is poorly understood. Here we show that similar to metformin treatment, loss of Oct1 caused an increase in the ratio of AMP to ATP,...

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書誌詳細
主要な著者: Chen, Ligong, Shu, Yan, Liang, Xiaomin, Chen, Eugene C., Yee, Sook Wah, Zur, Arik A., Li, Shuanglian, Xu, Lu, Keshari, Kayvan R., Lin, Michael J., Chien, Huan-Chieh, Zhang, Youcai, Morrissey, Kari M., Liu, Jason, Ostrem, Jonathan, Younger, Noah S., Kurhanewicz, John, Shokat, Kevan M., Ashrafi, Kaveh, Giacomini, Kathleen M.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2014
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103324/
https://ncbi.nlm.nih.gov/pubmed/24961373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314939111
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