Effect of Genetic Variation in the Organic Cation Transporter 2, OCT2, on the Renal Elimination of Metformin

OBJECTIVE: The goal of this study was to determine the effect of a genetic variant in the organic cation transporter (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, on the pharmacokinetics of the anti-diabetic drug, metformin. METHODS: The uptake of metformin was performed in stab...

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Detalhes bibliográficos
Main Authors: Chen, Ying, Li, Shuanglian, Brown, Chaline, Cheatham, Stephen, Castro, Richard A., Leabman, Maya K., Urban, Thomas J., Chen, Ligong, Yee, Sook Wah, Choi, Ji Ha, Huang, Yong, Brett, Claire M., Burchard, Esteban G., Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104496/
https://ncbi.nlm.nih.gov/pubmed/19483665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832cc7e9
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