Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unkn...

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Detalhes bibliográficos
Main Authors: Shu, Yan, Sheardown, Steven A., Brown, Chaline, Owen, Ryan P., Zhang, Shuzhong, Castro, Richard A., Ianculescu, Alexandra G., Yue, Lin, Lo, Joan C., Burchard, Esteban G., Brett, Claire M., Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857259/
https://ncbi.nlm.nih.gov/pubmed/17476361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30558
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