Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice

PURPOSE: The goal of this study was to test the hypothesis that by controlling intracellular uptake, organic cation transporter 1, Oct1 is a key determinant of the disposition and toxicity of cis-diammine(pyridine)chloroplatinum(II)(CDPCP) and oxaliplatin. METHODS: Pharmacokinetics, tissue accumulat...

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Autori principali: Li, Shuanglian, Chen, Ying, Zhang, Shuzhong, More, Swati S., Huang, Xiaozhu, Giacomini, Kathleen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2010
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040319/
https://ncbi.nlm.nih.gov/pubmed/21104302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0312-6
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