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Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics

The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy volunteers with known OCT1 genotype agreed to participate in the study. Each subject received two oral doses...

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Detalhes bibliográficos
Main Authors: Shu, Y, Brown, C, Castro, RA, Shi, RJ, Lin, ET, Owen, RP, Sheardown, SA, Yue, L, Burchard, EG, Brett, CM, Giacomini, KM
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976713/
https://ncbi.nlm.nih.gov/pubmed/17609683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.clpt.6100275
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