Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics

The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy volunteers with known OCT1 genotype agreed to participate in the study. Each subject received two oral doses...

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Главные авторы: Shu, Y, Brown, C, Castro, RA, Shi, RJ, Lin, ET, Owen, RP, Sheardown, SA, Yue, L, Burchard, EG, Brett, CM, Giacomini, KM
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976713/
https://ncbi.nlm.nih.gov/pubmed/17609683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.clpt.6100275
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