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Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters, OCTs, and Multidrug and Toxic Compound Extrusion Proteins, MATEs

The drug-drug interaction (DDI) potential of tyrosine kinase inhibitors (TKIs) as interacting drugs via transporter inhibition has not been fully assessed. Here, we estimated the half maximal inhibitory concentration (IC(50)) values for eight small-molecule TKIs (imatinib, dasatinib, nilotinib, gefi...

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Detalhes bibliográficos
Main Authors: Minematsu, Tsuyoshi, Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063525/
https://ncbi.nlm.nih.gov/pubmed/21252289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0731
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