Genetic Variants in Multidrug and Toxic Compound Extrusion 1, hMATE1, Alter Transport Function

hMATE1 (human multidrug and toxin compound extrusion-1; encoded by SLC47A1) is thought to have an important function in the renal and hepatic elimination of drugs, endogenous compounds and environmental toxins. The goals of this study were to identify genetic variants of hMATE1 and to determine thei...

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Main Authors: Chen, Ying, Teranishi, Kristen, Li, Shuanglian, Yee, Sook Wah, Hesselson, Stephanie, Stryke, Doug, Johns, Susan J., Ferrin, Thomas E., Kwok, Pui, Giacomini, Kathleen M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949062/
https://ncbi.nlm.nih.gov/pubmed/19172157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2008.19
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