Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in m...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Chen, Eugene C., Liang, Xiaomin, Yee, Sook Wah, Geier, Ethan G., Stocker, Sophie L., Chen, Ligong, Giacomini, Kathleen M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468641/
https://ncbi.nlm.nih.gov/pubmed/25920679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096776
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