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Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in m...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Chen, Eugene C., Liang, Xiaomin, Yee, Sook Wah, Geier, Ethan G., Stocker, Sophie L., Chen, Ligong, Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468641/
https://ncbi.nlm.nih.gov/pubmed/25920679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096776
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