Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in m...

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Publicat a:Mol Pharmacol
Autors principals: Chen, Eugene C., Liang, Xiaomin, Yee, Sook Wah, Geier, Ethan G., Stocker, Sophie L., Chen, Ligong, Giacomini, Kathleen M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468641/
https://ncbi.nlm.nih.gov/pubmed/25920679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096776
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