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Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin
Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in m...
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| Veröffentlicht in: | Mol Pharmacol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468641/ https://ncbi.nlm.nih.gov/pubmed/25920679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096776 |
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