Role of Organic Cation Transporter 3 (SLC22A3) and Its Missense Variants in the Pharmacologic Action of Metformin

OBJECTIVES: The goals of this study were to determine the role of OCT3 in the pharmacologic action of metformin and to identify and functionally characterize genetic variants of OCT3 with respect to the uptake of metformin and monoamines. METHODS: For the pharmacologic studies, we evaluated metformi...

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Autori principali: Chen, Ligong, Pawlikowski, Bradley, Schlessinger, Avner, More, Swati S., Stryke, Doug, Johns, Susan J., Portman, Michael A., Chen, Eugene, Ferrin, Thomas E., Sali, Andrej, Giacomini, Kathleen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976715/
https://ncbi.nlm.nih.gov/pubmed/20859243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833fe789
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